Development of single-vial kit for simple and convenient formulation of 68Ga-NODAGA-JR11: PET agent for diagnosis of neuroendocrine tumor
Creators
- 1. Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
Description
68Ga-NODAGA-JR11 has emerged as a promising somatostatin antagonist for PET-imaging of neuroendocrine tumors. Preliminary success of the agent necessitates further multicentric clinical trials for complete evaluation in human cancer patients. Single-step formulation of 68Ga-NODAGA-JR11 at hospital radiopharmacy shall encourage increased participation of hospitals facilitating multi-centre trials. Thus, freeze-dried kits were developed for convenient formulation of 68Ga-NODAGA-JR11 and preliminary clinical studies were performed in neuroendocrine cancer patients. Kit formulated 68Ga-NODAGA-JR11 exhibited high uptake in primary as well as metastatic lesions.
Additional details
Identifiers
Publishing Information
- Journal Title
- BARC Newsletter
- Journal Page Range
- 13-15
- ISSN
- 0976-2108
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S07: ISOTOPES AND RADIATION SOURCES;
- Descriptors DEI
- CLINICAL TRIALS; DIAGNOSIS; EVALUATION; FLUORINE 18; FLUORODEOXYGLUCOSE; GALLIUM 67; GERMANIUM 68; HOSPITALS; IODINE 124; METASTASES; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; RADIOIMMUNOTHERAPY; RADIOPHARMACEUTICALS; SOMATOSTATIN; UPTAKE
- Descriptors DEC
- ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BUILDINGS; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; EVEN-EVEN NUCLEI; FLUORINE ISOTOPES; GALLIUM ISOTOPES; GERMANIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; IMMUNOTHERAPY; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEDICAL ESTABLISHMENTS; MEDICINE; NANOSECONDS LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; TESTING; THERAPY; TOMOGRAPHY