Published 1989 | Version v1
Miscellaneous Metadata-only

Peculiarities of neoplasm reaction in case of combined effect of interferon synthesis inductors and radiation

Creators

Description

Autitumoral antimetastatic effect of certain interferon synthesis inductors of various classes are studied including poly I, poly Ts, tyloron, curantyl in combination with irradiation using sarcoma-37 and Lewis carcinoma models. When investigating different synthetic interferon synthesis inductors differing by synthesis terms and endogenous interferon titers, an insulficient radiosensitizing effet on sarcoma-37 tumor is detected. The most obvious effect of the same inductors was observed in Lewis carcinoma: the number of secondary tumors (metastases) is 2.0-2.5 times reduced when the inductor is injected a day before irradiation. 11 refs.; 4 tabs

Additional details

Additional titles

Original title (Russian)
Особенности реакции опухоли при сочетанном действии индукторов синтеза интерферона и радиации

Publishing Information

Imprint Title
Interferon inductors and other immunomodulators in radiology and oncology
Imprint Pagination
126 p.
Journal Page Range
p. 28-35.
Report number
INIS-SU--131/A

INIS

Country of Publication
USSR
Country of Input or Organization
USSR
INIS RN
20075736
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOSYNTHESIS; CARCINOMAS; CHEMICAL ACTIVATION; FLUORENE; GAMMA RADIATION; INTERFERON; LIFE SPAN; METASTASES; MICE; RESPONSE MODIFYING FACTORS; SARCOMAS; TUMOR CELLS; VASODILATORS
Descriptors DEC
ANIMAL CELLS; ANIMALS; AROMATICS; BIOLOGICAL EFFECTS; CARDIOVASCULAR AGENTS; CONDENSED AROMATICS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HYDROCARBONS; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; SYNTHESIS; VERTEBRATES

Optional Information

Notes
Imprint:TB-02943.;Induktory interferona i drugie immunomodulyatory v radiologii i onkologii.;Sbornik nauchnykh trudov.