Published February 1, 1995
| Version v1
Journal article
Synthesis of 195mPt radiolabeled cisdiammine(glycolato)platinum(II) of high radionuclidic purity
- 1. Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst.
- 2. Robert Koch Inst., Berlin (Germany)
Description
An experimental method is described for the synthesis of 195mPt-radiolabeled cis-diammine(glycolato)platinum(II) (254-S). Ten mg of 95% enriched 194Pt was irradiated for 75 h in the hydraulic conveyer of KUR at a thermal neutron flux of ca. 8.15 x 1013 n x cm-2 x s-1, and the 195mPt-radiolabeled 254-S was synthesized and purified using HPLC (column: Dichrosorb Diol, elution: 80% CH3Cn). The chemical yield was approximately 45%, with chemical purity greater than 98.4 %. The radionuclidic purity was nearly 100% and the specific activity, 7.2 MBq x mg-1 254-S. (author) 10 refs.; 4 figs.; 1 tab
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 199
- Journal Issue
- 3
- Journal Page Range
- p. 207-215.
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 26036422
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; ISOTOPE ENRICHED MATERIALS; PLATINUM COMPLEXES; PLATINUM 195; RADIOPHARMACEUTICALS
- Descriptors DEC
- COMPLEXES; DAYS LIVING RADIOISOTOPES; DRUGS; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; PLATINUM ISOTOPES; RADIOACTIVE MATERIALS; RADIOISOTOPES; STABLE ISOTOPES; SYNTHESIS; TRANSITION ELEMENT COMPLEXES; YIELDS