Published 1985 | Version v1
Journal article

Effect of X-ray irradiation on interaction between phenylobutazone and hexobarbital

  • 1. Akademia Medyczna, Poznan (Poland)

Description

The effect of premedication with phenylobutazone (60 mg/kg i.p.) on the hypnotic activity of hexobarbital (100 mg/kg i.p.) in rats irradiated with X-rays (600 R) was examined. After premedication with phenylobutazone hexobarbital-induced sleep was significantly longer, especially on the 3rd day of postirradiation sickness. Prolonged biological half-life time of hexobarbital and higher level in brain could explain its longer hypnotic effect. 33 refs., 3 figs., 3 tabs. (author)

Additional details

Additional titles

Original title (Polish)
Wplyw napromieniania promieniami X na interakcje fenylobutazonu z heksobarbitalem

Publishing Information

Journal Title
Poznanskie Roczniki Medyczne
Journal Volume
9
Series
Poznan. Rocz. Med.
Journal Page Range
37-45
ISSN
0137-5350
CODEN
POMDD