Clinical study of efficacy and delayed complications of superselective intra-arterial Cisplatin infusion chemotherapy combined with radiotherapy and surgery for advanced maxillary squamous cell carcinoma

Thirty patients (19 males, 11 females) with advanced maxillary squamous cell carcinoma received superselective intra-arterial Cisplatin infusion chemotherapy combined with radiotherapy and surgery for maxillary squamous cell carcinoma. The five-year overall survival rate and cause-specific rate were 83.1% and 89.6% for all patients, respectively. Regarding clinical T stage, the five-year cause-specific survival rate was 100% in T3 and 84.7% in T4. As for the preservation of organ function, all 30 patients retained orbital contents and 26 patients retained hard plate after initial treatment. Regarding delayed complications of these series of treatments, loss of ocular function occurred in two patients and deformity of the cheek occurred in 5 patients. These results suggested the clinical efficacy of superselective intra-arterial Cisplatin infusion chemotherapy combined with radiotherapy and surgery, but the occurrence of delayed complications must be considered. (author)