Published 1975
| Version v1
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Physiopathology of blood platelets and development of platelet substitutes. Progress report, August 1, 1974--July 31, 1975
Description
Progress is reported on investigations of methods for the storage of human blood platelets. Good results were obtained when platelets were frozen using 5 percent dimethyl sulfoxide (DMSO) as a cryoprotective agent. There was no evidence of toxic effects of trace amounts of DMSO in experimental animals. Blood platelet storage at 220C with nucleotide additives in the storage medium was also investigated. The effects of x irradiation at doses varying from 100 to 1000 R on the aggregation of blood platelets following exposure in vitro and the effect of Vitamin E as an antiaggregating agent were studied. (U.S.)
Availability note (English)
MF available from INIS under the Report Number.
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Additional details
Additional titles
- Augmented title (English)
- Storage of human blood platelets
Publishing Information
- Imprint Pagination
- 49 p.
- Report number
- COO--3234-25
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 7220116
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- ADDITIVES; BIOLOGICAL RADIATION EFFECTS; BLOOD PLATELETS; DMSO; FREEZING; IN VITRO; IRRADIATION; NUCLEOTIDES; RADIATION DOSES; RESPONSE MODIFYING FACTORS; STORAGE; TEMPERATURE DEPENDENCE; TOXICITY; VITAMIN E; X RADIATION
- Descriptors DEC
- BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATION EFFECTS; RADIATIONS; SULFOXIDES; VITAMINS