Changes of the oral mucosa during local UHF-hyperthermia and radiation therapy of malignant tumors of maxillofacial area

Morphological investigations under experimental conditions have demonstrated that local UHF-hyperthermia at 42-43 deg C for 30 min does not cause alterative changes of the oral mucosa in animals. In patients local UHF-hyperthermia had a radiosensitizing effect on the oral mucosa at 40-41.5 deg C for 30 and 60 min. However it did not prevent the completion of a radical split course in the regimen of dynamic dose fractionation nor did it increase the number of postradiation complications. Under this temperature-time regimen the time of development and a degree of expression of radiation reactions did not depend on the succession of hyperthermia and irradiation, and the time of heating