The inhibition effect of 211At-Te colloid and Na211 at injections on murine Ehrlich ascites tumor cells
Description
Na 211At and 211At-Te colloid injections are prepared. It has been demonstrated that the 211At-Te colloid is stable in vivo and in vitro, and can be applied in the study of biology and medicine. In the report, the model of Murine Ehrlich Ascites Cells cultured in vivo and in vitro is elected for a series of experiments. It has been proved that Na 211At and 211At-Te colloid injections possess an inhibition effect on tumor cells. The inhibition effect was expressed in surviving of the mice and inhibiting growth of tumor as well as the changes of enzyme activity. Meanwhile, it was also noticed that Na 211At and 211At-Te colloid injections of various dose inhibited the absorb of pyrimidine nucleosides in Murine Ehrlich Ascites Cells. And the effect is not reversible. It is closely related to the dose administrated and 50% inhibition rate needs about 1.48 x 105 Bq/ml culture
Additional details
Publishing Information
- Journal Title
- Nuclear Science and Techniques
- Journal Volume
- 3
- Journal Issue
- 1
- Journal Page Range
- p. 40-44.
- ISSN
- 1001-8042
- CODEN
- NSETEC
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 24038322
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ASCITES TUMOR CELLS; ASTATINE COMPOUNDS; ASTATINE 211; EHRLICH ASCITES TUMOR; INHIBITION; RADIOCOLLOIDS; RADIOPHARMACEUTICALS; RADIOTHERAPY; SODIUM COMPOUNDS; TELLURIDES
- Descriptors DEC
- ALKALI METAL COMPOUNDS; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; CHALCOGENIDES; COLLOIDS; DISEASES; DISPERSIONS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EXPERIMENTAL NEOPLASMS; HALOGEN COMPOUNDS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; TELLURIUM COMPOUNDS; THERAPY; TUMOR CELLS