Ornidazole-loaded polyethylene glycol-based micron-level particles: influence of eutectic liquid on reservoir-type particle formation, drug entrapment efficiency and drug dissolution or release behavior

A temperature-controlled dispersion technique was used to develop ornidazole-loaded micron-level particles. To overcome the problem of generating the reservoir-type particles from polyethylene glycol, the influence of camphor and menthol (1:1 ratio)-based eutectic liquid on reservoir-type particle formation, drug entrapment efficiency and drug release behavior was examined. A distinct wall formation was observed for the particles on contact with water. Higher drug entrapment efficiency (~ 15–20%) was noted for the particles prepared with eutectic liquid. Significantly, (one-way ANOVA) higher t_50% values (35.16 ± 1.44 min for HCl and 43.6 ± 0.76 min for pH 6.8 phosphate buffer) were noticed for the eutectic liquid-based particles in comparison with the t_50% values (30.66 ± 0.76 min for HCl and 35.5 ± 0.86 min for pH 6.8 phosphate buffer) observed for the particles made without the same. The potential of eutectic liquid to generate the microcapsule structure should be explored further.