Published March 1977 | Version v1
Journal article Metadata-only

The effect of erythromycin and its thiocarbamide derivative on the induction of meiotic chromosome rearrangements in irradiated male mice

Creators

  • 1. Institut za Nuklearne Nauke Boris Kidric, Belgrade (Yugoslavia). Radiobiological Lab.
  • 2. Novi Sad Univ. (Yugoslavia). Inst. of Chemistry
  • 3. Pharmaceutical Industry 'Galenika', Belgrade (Yugoslavia)

Description

Antibiotics, erythromycin and a thiocarbamide derivative of erythromycin were tested for their ability to induce chromosome translocations in whole-body irradiated mice with a dose of 600 r. The aim of the present paper was to determine whether these antibiotics might induce by themselves, chromosomal translocations and whether these agents have a protective effect against X-rays-induced chromosomal translocations in the spermatocytes at the first meiotic metaphase. The incidence of translocations in irradiated animals was 9.07%; in animals treated with erythromycin after irradiation it was 3.80%; and in those treated with a thiocarbamide derivative of erythromycin following irradiation was 3.20%. Not a single chromosome rearrangement was scored among the non-irradiated animals, treated with the mentioned antibiotics. (orig.)

Abstract (German)

Das Antibiotikum Erythromycin und sein Thioharnstoffderivat wurden mit Hinsicht auf moegliche Induktion chromosomaler Translokationen bei Maeusen, bestrahlt mit einer Dosis von 600 r, untersucht. Das Ziel dieser Arbeit war festzustellten, ob diese Antibiotika selbst eine chromosomaler Translokation hervorrufen und ob sie einen Schutzeffekt hinsichtlich der mit X-Strahlen induzierten chromosomalen Translokationen in der ersten meiotischen Metaphase aufweisen. Die Translokationen-Frequenz bei den nur bestrahlten Tieren war 9,07%, bei den nach Bestrahlung mit Erythromycin behandelten 3,80%, bei den bestrahlten und mit den Thioharnstoffderivat behandelten 3,20%. Bei den mit den angefuehrten Antibiotika ohne Bestrahlung behandelten Tieren wurden keine chromosomalen Stoerungen beobachtet. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
153
Journal Issue
3
Series
Strahlentherapie.
Journal Page Range
200-203

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
8324599
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL REPAIR; CHROMOSOMAL ABERRATIONS; ERYTHROMYCIN; GENETIC RADIATION EFFECTS; MEIOSIS; MICE; MUTAGENESIS; SPERMATOCYTES; TESTES; THIOUREA; WHOLE-BODY IRRADIATION; X RADIATION
Descriptors DEC
ANIMALS; ANTIBIOTICS; ANTITHYROID DRUGS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BODY; CARBONIC ACID DERIVATIVES; CELL DIVISION; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GENETIC EFFECTS; GERM CELLS; GONADS; IONIZING RADIATIONS; IRRADIATION; MALE GENITALS; MAMMALS; MUTATIONS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; THIOUREAS; VERTEBRATES

Optional Information

Notes
3 tabs.; 21 refs.