A Software Package of Quantitative SPECT Image Reconstruction for Measurement of Physiological in Vivo Parameter

Accurate estimation of radioactivity is essential for the quantitative measurement of physiological in vivo parameter in the medical field using nuclear medicine imaging. Among many nuclear medicine modalities, single photon emission computed tomography (SPECT) has been widely used in many clinical studies. Many SPECT studies with quantitative manner have been reported and evaluated, which have been contributed to the advance of SPECT technique and wide spread of its use. However, SPECT is still not employed in quantitative study as much as positron emission tomography (PET) has done. Recently, we reported an approach to quantify radioactivity accurately using SPECT, and evaluated its applicability in real measurement of physiological parameter [1-8]. Based on these reports, we developed a software package (QSPECT) for image reconstruction of SPECT data