Published January 1991 | Version v1
Journal article Metadata-only

Effect of radiation and alkylating agents on chromatin degradation in normal and malignant lymphoid cells

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Obninsk (USSR). Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii

Description

Regularities of chromatin degradation in thymocytes and LS/BL tumor cells have been investigated. It has been shown that the rate of DNA degradation by Ca/Mg-dependent endonuclease in LS/BL tumor cells is 25 times lower than that in thymocytes, and radiation does not induce chormatin degradation. The alkylating agent TS 160 causes chromatin degradation in both LS/Bl cells and thymocytes. In contrast to radiation TS 160 inhibits the endogenous chromatin degradation by Ca/Mg-dependent endonuclease in thymocytes

Additional details

Additional titles

Original title (Russian)
Влияние облучения и алкилирующих агентов на распад хроматина в нормальных и малигнизированных лимфоидных клетках

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
31
Journal Issue
1
Series
Radiobiologiya.
Journal Page Range
22-26
ISSN
0033-8192
CODEN
RADOA

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
23016793
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ALKYLATING AGENTS; BIOLOGICAL RADIATION EFFECTS; CHROMATIN; COBALT 60; DECOMPOSITION; DNA; LYMPHOSARCOMAS; MICE; RESPONSE MODIFYING FACTORS; THYMOCYTES
Descriptors DEC
ANIMAL CELLS; ANIMALS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CHEMICAL REACTIONS; COBALT ISOTOPES; DISEASES; DRUGS; IMMUNE SYSTEM DISEASES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LYMPHOMAS; MAMMALS; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SARCOMAS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES