Regression of pulmonary arterial hypertension and short term clinical outcome in patients with mitral valve replacement

Objective: To determine the regression of pulmonary arterial hypertension inpatients with Mitral valve disease after mitral valve replacement. Methodology: This cross sectional study was conducted was at Cardiac Surgery department of Punjab Institute of Cardiology from 1st March 2013 to 2014. Patients undergoing Mitral valve replacement for rheumatic valvular disease, aged 15 to 60 years were selected. Patients with aortic valve disease and coronary artery disease, severe renal impairment (creatinine clearance less than 40 ml/min), moderate to severe left ventricular dysfunction i.e. EF<40 percent were excluded from the study. Pre and post 24 hour Echocardiography was performed to measure pulmonary arterial hypertension (mPASP) of> 60 mmHg. Results: PASP returns to near normal values in the majority of patients with severe pulmonary arterial hypertension after MVR and the decrease is significant. Conclusion: PASP returns to near normal values in the majority of patients with severe pulmonary arterial hypertension after MVR and the decrease is significant. (author)