Published 1989 | Version v1
Report Metadata-only

Some remarks on the radiation induced cancerogenesis in the range of small doses

Creators

  • 1. Akademie der Wissenschaften der DDR, Berlin (Germany, F.R.). Zentralinstitut fuer Krebsforschung
  • 2. Akademie der Wissenschaften der DDR, Berlin (Germany, F.R.). Zentralinstitut fuer Molekularbiologie

Description

It is shown that repair efficiency of DNA single strand breaks induced by low dose irradiation can have an inhibiting action on manifestation of spontaneous DNA defects by means of enzymatic elimination of single strand breaks. With increasing dose and LET the inhibition effect of the single strand breaks gets competition with certain irreparable double strand break patterns, which are causing the radiation-induced cell transformations via chromosomal rearrangements. Turther investigations on repair mechanism are required. The problem of radiation carcinogenesis can be solved only in stimulating cooperation between radiation and molecular biology

Additional details

Additional titles

Original title (no language)
Trudy rabochego soveshchaniya po geneticheskomu dejstviyu korpuskulyarnykh izluchenij.

Publishing Information

Imprint Title
Proceedings of the workshop on genetic effects of charged particles
Imprint Pagination
303 p.
Journal Page Range
p. 238-240.
Report number
JINR-D--19-89-143

Conference

Title
Workshop on genetic effects of charged particles.
Dates
4-6 Oct 1988.
Place
Dubna (USSR).

INIS

Country of Publication
USSR
Country of Input or Organization
USSR
INIS RN
22008274
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; CHROMOSOMAL ABERRATIONS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIPS; IN VITRO; IN VIVO; LET; LOW DOSE IRRADIATION; MOLECULAR BIOLOGY; STRAND BREAKS
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ENERGY TRANSFER; IRRADIATION; MUTATIONS; PATHOGENESIS; RADIATION EFFECTS

Optional Information

Notes
Imprint:Trudy rabochego soveshchaniya po geneticheskomu dejstviyu korpuskulyarnykh izluchenij.