Published February 29, 1988 | Version v1
Journal article Metadata-only

A high density of muscarenic receptors in the rostral ventrolateral medulla of the rat is revealed by correction for autoradiographic efficiency

Creators

  • 1. Laboratory of Neurobiology, Cornell Univ. Medical College, New York (USA)

Description

Previous reports of a low density of muscarenic receptors in the vicinity of the rostral ventrolateral medulla (RVL) conflict with the presence of a muscarenic cholengic mechanism regulating arterial pressure and may reflect low autoradiographic efficiency due to quenching of tritium emissions by white matter. Regional autoradiographic efficiency was determined using brains uniformly labelled with O-[3H]methylglucose. Within the RVL, autoradiographic efficiency was only 50±2% relative to grey matter. The uncorrected density of muscarenic receptors labelled by [3H] quinuclidinyl benzilate in the RVL appeared to be low. We conclude that a high density of muscarenic acetyl cholie receptors is present in the RVL

Additional details

Publishing Information

Journal Title
Neurosci. Lett.
Journal Volume
85
Journal Issue
2
Series
Neurosci. Lett.
Journal Page Range
179-186
ISSN
0304-3940
CODEN
NELED

INIS

Country of Publication
Ireland
Country of Input or Organization
Ireland
INIS RN
19104974
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ACETYLCHOLINE; AUTORADIOGRAPHY; BRAIN; DENSITY; EFFICIENCY; LABELLED COMPOUNDS; RECEPTORS
Descriptors DEC
AMINES; AUTONOMIC NERVOUS SYSTEM AGENT; BODY; CENTRAL NERVOUS SYSTEM; DRUGS; ESTERS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PARASYMPATHOMIMETICS; PHYSICAL PROPERTIES; QUATERNARY COMPOUNDS