Therapeutic effect of pilose antler polypeptides (PAP) on experimental fracture and its mechanism
Creators
- 1. Changchun College of Traditional Chinese Medicine, Changchun (China). Research Centre of New Drug
- 2. Institute of Preclinical Sciences, NBUMS (China)
Description
Objective: To test the therapeutic effect of PAP on experimental fracture and its mechanism. Methods: Effect of PAP on the incorporation of [3H]-TdR into DNA syntheses in the cells of rabbits costal cartilage and human embryonic joint as well as osteoblast precursor cells of embryonic chick calvaria in vitro and effect of PAP on the experimental radius fracture in rats in vivo were observed. Results: PAP of 10∼50 μg·ml-1 showed mitogenic activities and significant promotion of DNA syntheses for various cartilage cells in vitro. In vivo experimental results revealed that PAP 10 and 20 mg·kg-1 could promote healing of radius fracture, accelerate osteotylus formation and increase contents of calcium and oxyproline. Conclusion: PAP accelerates fracture healing through promoting multiplications of cartilage and osteoblast precursor cells, collagen accumulation and calcium precipitation in osteotylus
Additional details
Publishing Information
- Journal Title
- Journal of Norman Bethune University of Medical Sciences
- Journal Volume
- 25
- Journal Issue
- 5
- Journal Page Range
- p. 586-588
- ISSN
- 0253-3707
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 31007542
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTLERS; CARTILAGE; CELL PROLIFERATION; CHICKENS; DNA; EMBRYONIC CELLS; FRACTURES; MITOGENS; POLYPEPTIDES; RABBITS; RATS; SKELETON; SYNTHESIS; TRITIUM
- Descriptors DEC
- ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIRDS; BODY; BONE TISSUES; CONNECTIVE TISSUE; FAILURES; FOWL; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDES; PROTEINS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES