Published June 1991
| Version v1
Journal article
Syntheses of poly-deuterated 9(O)-methano-Δ6(9α)-prostaglandin I1 methyl esters
- 1. Inst. for Bio-Medical Research, Teijin Ltd., Tokyo (Japan)
Description
Two types of poly-deuterated isocarbacyclin [9(O)-methano-Δ6(9α-prostaglandin I1) ] methyl ester have been synthesized for the use of GC-MS quantitative analysis as internal standards and for the use of metabolic study as substrates. The 5,13,14-2H3 derivative 2 was prepared via H-D exchange, deuteroboration, and sodium borodeuteride reduction. The 2,2,3,3,4,4-2H6 derivatives 3,4 were prepared starting from tetrahydrofuran-d8. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 29
- Journal Issue
- 6
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 667-680
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 23010655
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CALIBRATION STANDARDS; CHEMICAL PREPARATION; DEUTERATION; DEUTERIUM; ISOTOPIC EXCHANGE; LABELLING; METABOLISM; PROSTAGLANDINS; RADIOPHARMACEUTICALS
- Descriptors DEC
- CHEMICAL REACTIONS; DRUGS; HYDROGEN ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; STABLE ISOTOPES; STANDARDS; SYNTHESIS