Radioimmunodetection of tumors using labelled antibodies in experiment

The experiments were performed using genetically athymic mice (BALB/C, nu/nu) with xenotransplants from human neoplasms. Three types of rectum adenocarcinoma, the human HeLa tumor line and the bladder tumor T-24 line were transplanted to the mice. Polyclonal sheep and rabbit antibodies were prepared and monoclonal mouse antibody 7E9 imported from Sweden was tested. In all experiments, the antibodies were labelled with 131I and were i.v. injected. Scans were performed at certain time intervals. Radioactivity distribution in the blood and the individual organs was studied five to six days following the application of the antibodies. The results obtained using the antibodies are discussed and the problems of radioimmunodetection of tumors are outlined. (E.S.)