Published December 1988
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The role of macrophage derived growth factors in pulmonary fibrosis
Description
Factors released from rat alveolar macrophages exposed to high (95 μg/mL) concentrations of the fibrogenic agent, nickel subsulfide, were found to inhibit the proliferation of cultured lung epithelial cells and stimulate the growth of fibroblasts. Such factors, if present in the alveoli of rats exposed by inhalation to nickel subsulfide in vivo, may play a role in inhibiting re-epithelization of nickel-damaged lungs and in stimulating fibroblast proliferation, leading to pulmonary fibrosis. (author)
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Additional details
Publishing Information
- Imprint Title
- Inhalation Toxicology Research Institute annual report 1987-1988
- Imprint Pagination
- 659 p.
- Journal Page Range
- p. 469-474
- Report number
- LMF--121
INIS
- Country of Publication
- International Atomic Energy Agency (IAEA)
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 36003670
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- FIBROBLASTS; FIBROSIS; GROWTH FACTORS; IN VIVO; INHALATION; LUNGS; MACROPHAGES; NICKEL; RATS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BODY; CONNECTIVE TISSUE CELLS; ELEMENTS; INTAKE; MAMMALS; METALS; MITOGENS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PHAGOCYTES; PROTEINS; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; TRANSITION ELEMENTS; VERTEBRATES
Optional Information
- Contract/Grant/Project number
- Contract DE-AC04-76EV01013
- Notes
- 9 refs, 5 figs, 2 tabs
- Secondary number(s)
- INIS-XA-N--170