Loading of ¹⁷⁷Lu-PSMA-617 on biodegradable nanofiberous patch for the therapeutic purpose of residual tumours after resection – A novel radiopharmaceutical therapy system

One of the leading causes of mortality globally is cancer. The foundation of today's cancer treatments are surgery, chemotherapy, and radiation. The aim of this study was to encapsulate ¹⁷⁷Lu- PSMA-617 and release of radiation from biodegradable nanofibers loaded with ¹⁷⁷Lu-PSMA-617. We prepared a ¹⁷⁷Lu-PSMA-617 loaded nanofibrous patch, assembled from biodegradable soya protein and silk fibroin. Nanofibers were prepared in three different ratios: Type-I SPI: SF; 75:25 (w/w), Type-II SPI: SF;50:50 (w/w), and Type-III SPI: SF;25:75 (w/w). 2mCi of ¹⁷⁷Lu-PSMA-617 was added to each fibrous patch. The slow, sustained delivery of radiation in vivo may increase the induction of apoptosis in residual tumor cells and inhibition of tumor angiogenesis. We concluded that ¹⁷⁷Lu-PSMA-617 loaded with nanofibers could be introduced as a promising treatment for implantation upon post-surgery of the tumour. Animal studies will be evaluated in the next step of studies