Method of determination of radiochemical purity of gallium-67 citrate injection

A simple method is used to compare the effect of five developing agents on the radiochemical purity of neutral products of 67GaCit and on Rsub(f) values. Two preferable developing agents are recommended as suitable for the identification of 67GaCit injection in its production. The effect of six pH values of different developing agents on radiochemical purity, Rsub(f) and chromatogram are compared for the neutral products. The results of the experiments show that the ascending paper chromatography with 1:2:4 pyridine/ethanol/water and 85:15 methanol/water is preferable for the determination of the radiochemical purity of 67GaCit. The other developing agents also can be used if there are not any impurities except gallium radioisotopes