Published January 2022
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Subunit association, (UN) folding dynamics of CIA17 at low pH: a spectroscopic and microscopic study
- 1. School of Chemistry, University of Hyderabad, Hyderabad (India)
Description
We demonstrate here the low pH induced perturbation in the structure, conformational dynamics of Cocciniaindica agglutinin (CIA17). While tertiary structure of the protein exhibits considerable changes, secondary structure of CIA17 remains almost unaltered. FCS studies revealed that CIA17at pH-2.0 exists as a monomeric intermediate in a concentration range ∼10nM-200nM and forms dimers at higher concentrations (KD≈387 nM). The intermediates retain carbohydrate binding specificity considerably. (author)
Additional details
Publishing Information
- Publisher
- Bhabha Atomic Research Centre
- Imprint Place
- Mumbai (India)
- Imprint Title
- Proceedings of the sixteenth DAE-BRNS biennial Trombay symposium on radiation and photochemistry
- Imprint Pagination
- 392 p.
- Journal Page Range
- p. 189-190
Conference
- Title
- 16. DAE-BRNS biennial Trombay symposium on radiation and photochemistry
- Acronym
- TSRP-2022
- Dates
- 12-15 Jan 2022
- Place
- Mumbai (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 54031791
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CARBOHYDRATES; CONCENTRATION RATIO; PH VALUE; PROTEINS; SPECTROSCOPY
- Descriptors DEC
- DIMENSIONLESS NUMBERS; ORGANIC COMPOUNDS