Published 2018 | Version v1
Journal article Metadata-only

Radioiodinated celiprolol as a new highly selective radiotracer for β1-adrenoceptor-myocardial perfusion imaging

Creators

  • 1. Egyptian Atomic Energy Authority, Cairo (Egypt). Labeled Compounds Dept.
  • 2. Atomic Energy Authority, Cairo (Egypt). Health Radiation Research Dept. (Radiodiagnosis Unit)
  • 3. Delta Univ., Mansoura (Egypt). Dept. of Organic Pharmaceutical Chemistry

Description

The present study was oriented to synthesis radioiodinated celiprolol (Cel) for a potential cardiac imaging. Celiprolol has been labeled using 125I with chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize the iodination. The biological distribution indicates the suitability of radioiodinated Cel as a novel tracer to image heart.

Additional details

Publishing Information

Journal Title
Radiochimica Acta
Journal Volume
106
Journal Issue
9
Journal Page Range
p. 751-757
ISSN
0033-8230
CODEN
RAACAP

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
50000110
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL ACCUMULATION; BLOOD CIRCULATION; BLOOD FLOW; GAMMA CAMERAS; IODINATION; IODINE 125; MEGA BQ RANGE 01-10; MICE; MYOCARDIUM; OPTIMIZATION; PH VALUE; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; SCINTISCANNING; SUBSTRATES; TRACER TECHNIQUES; UPTAKE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CAMERAS; CARDIOVASCULAR SYSTEM; CHEMICAL REACTIONS; CHEMISTRY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HALOGENATION; HEART; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MEGA BQ RANGE; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOACTIVITY RANGE; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; VERTEBRATES