A new anticancer agent--131I BGTP

A new anticancer precursor, di-peptide[p-Boc-Gly-Tyr-NH(CH2)2 NH-PO (ONH4)-O-PhI*], was synthesized and labelled with 131I using enveloped-tube technique, the labelling yield could reach 85%. Using cell coalescent method, the biological activity in vitro of the labelled compounds was evaluated, showing that the primary appetency was kept and not damaged obviously during labelling. Results on judgement of their stability, lipophilicity and toxicity demonstrated lower toxicity, higher lipophilicity and lower iodium disassociation percentage (<12% after 72 h); furthermore, a tumour-bearing animal model, was establishd successfully, on which, the biological properties of the labelled agent was studied. (authors)