Dose-supplementary therapy of malignant tumors

It is well known that application of 10B - and Gd-containing drugs in neutron capture therapy (NCT) provides essential increase of local energy release, when the target area is irradiated with thermal neutrons. During the last time we are developing the photon capture therapy (PCT) technology. The physical principle of PCT consists in the increase of local energy release caused by the electrons of photo absorption and the accompanying Auger-cascade on atoms high-Z elements (Gd, Pt, Bi, etc.), which are present into the structure of special drugs at an irradiation of tumor low-energy photons. In both cases efficiency of the method determine not by only irradiation beam aiming on a tumor but also by selective concentration of a drug in a tumor cells or a target volume. Both NCT and PCT are binary technologies and their physical essence has a lot of similarities, keeping in mind a possibility of a local increasing of energy release particular in a clinical target area- tumor. Sometimes methods of a drug delivery into a tumor and dosimeter planning procedures in both cases are the same. Because of all above-both NCT and PCT can be united under a one common term dose-supplementary therapy'. (author)