Aerobic radiosensitization by SR 4233 in rodent and human cells: mechanistic and therapeutic implications

The finding of a difference between rodent and human cells with respect to post-irradiation sensitization by SR 4233, (3-amino-1,2,4-benzotriazine 1,4-dioxide) and the differing time-course kinetics for this effect as a function of how the drug and x-radiation are sequenced, suggest that while SR 4233 behaves in a radiomimetic manner in most respects, there may be subtle differences in the nature of the lesions produced by the drug, the important cellular targets for this damage, and/or the cell's management of the damage. (author)