Published January 1981 | Version v1
Journal article Metadata-only

DNA radiosensitivity in carcinoma of the human cervix

Creators

  • 1. Tokyo Univ. (Japan). Faculty of Medicine
  • 2. Jikei Univ., Tokyo (Japan). School of Medicine

Description

The radiosensitivity of DNA in human cervix carcinomas was examined by using alkaline sucrose gradient centrifugation to measure radiation-induced single-strand breaks. The DNA strand-break efficiencies observed in DNA of 18 specimens fell into two distinct groups, radiosensitive and radioresistant. The Difference in DNA radiosensitivity may be correlated with the pathological classifications of carcinomas. (orig.)

Abstract (German)

Die Strahlensensibilitaet der DNA aus menschlichen Zervixkarzinomen wurde mittels Messung der durch Strahlung erzeugten Einzelstrangbrueche festgestellt, wozu die im folgenden beschriebene Zentrifugationsmethode benutzt wurde (alkaline sucrose gradient centrifugation). Die Beobachtungen an der DNA in 18 Praeparaten ergaben aufgrund des Anteils der DNA-Strangbrueche zwei deutlich voneinander verschiedene Gruppen, eine strahlensensible und eine strahlenresistente. Die Unterschiede bei der DNA-Strahlensensibilitaet stehen moeglicherweise im Zusammenhang mit der pathologischen Klassifizierung der Karzinome. (orig.)

Additional details

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
157
Journal Issue
1
Series
Strahlentherapie.
Journal Page Range
33-35
ISSN
0039-2073

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
12638152
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CARCINOMAS; CESIUM 137; DNA; IN VITRO; PATIENTS; RADIOSENSITIVITY; RADIOTHERAPY; STRAND BREAKS; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CESIUM ISOTOPES; DISEASES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOISOTOPES; THERAPY; YEARS LIVING RADIOISOTOPES