Published September 2008 | Version v1
Journal article Metadata-only

Preparation of several bifunctional chelating agents for precursor [188Re(CO)3(H2O)3]+ and their radiolabelling and characterization

Creators

  • 1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang (China)

Description

Several representative bifunctional chelating agents (BFCA) molecules which can coordinate with [Re(CO)3 (H2O)3 ]+ were synthesized. On the NCA level, the ligands allow labelling yields > 95% with [188Re(CO)3 (H2O)3 ]+ under mild reaction conditions. Incubation of the corresponding 188 Re complexes in PBS buffer and human serum at 37 ℃ reveals good stabilities. Decomposition product is main 188ReO4-. The routine kit-preparation of the precursor [188Re(CO)3 (H2O)3 ]+ in combination with tailor-made ligand systems enables the organometallic labelling of biomolecules with unprecedented high specific activities. (authors)

Additional details

Publishing Information

Journal Title
Atomic Energy Science and Technology
Journal Volume
42
Journal Issue
suppl
Journal Page Range
p. 77-82
ISSN
1000-6931

Conference

Title
5. Symposium on Nuclear Technology Application of Beijing Nuclear Society
Dates
2008
Place
Beijing (China)

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
47094029
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BUFFERS; CHELATING AGENTS; COORDINATES; DECOMPOSITION; INCUBATION; LABELLING; LIGANDS; MAN; ORGANOMETALLIC COMPOUNDS; PRECURSOR; RHENIUM 188; RHENIUM COMPLEXES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; COMPLEXES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PRIMATES; RADIOISOTOPES; RHENIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; VERTEBRATES

Optional Information

Notes
3 tabs., 16 refs.