Published March 1992 | Version v1
Journal article Metadata-only

Kaopectate as a negative gastrointestinal contrast agent in MR imaging of colorectal disease

Creators

  • 1. RWTH Aachen, Klinik fuer Radiologische Diagnostik des Klinikums der Medizinischen Fakultaet (Germany)
  • 2. RWTH Aachen, Klinik fuer Chirurgie des Klinikums der Medizinischen Fakultaet (Germany)

Description

The potential of the generic kaopectate (Upjohn) as a negative rectal contrast agent in MR imaging was investigated in the assessment of colorectal disease. 45 MR examinations in patients with colorectal disease (colorectal carcinoma 25 patients, inflammatory disease 12 patients, miscellaneous disorders of the colon 8 patients) were evaluated. All examinations were performed with T1 and T2 weighted SE sequences after rectal application of kaopectate. Gd-DTPA enhanced T1 SE sequences were obtained as well. Kaopectate revealed a signal void of the lumen of the large intestine in T1 and T2 weighted SE sequences. Intravenous administration of Gd-DTPA enabled good differentiation of contrast-enhanced malignant or inflammatory tissue and the low signal lumen of the bowels. No side effects were noted. (orig.)

Abstract (German)

Die Eigenschaften des Antidiarrhoikums Kaoprompt-H (Upjohn) als negatives rektales MRT-Kontrastmittel wurden bei 45 Patienten mit kolorektalen (kolorektale Karzinome n=25; Dickdarmentzuendungen n=12; Varia n=8) Erkrankungen untersucht. Kaoprompt-H zeichnet sich durch einen guten negativen Kontrast zwischen Darmlumen und Umgebung auf T1- und T2-gewichteten SE-Aufnahmen aus. Die zusaetzliche i.v. Gd-DTPA-Applikation verbesserte die Abgrenzung kontrastaufnehmender entzuendlicher oder malignomer Darmwandlaesionen zu dem signalarmen Darmlumen. Nebenwirkungen des Kaoprompt-H wurden nicht beobachtet. (orig.)

Additional details

Additional titles

Original title (German)
MR-Tomographie kolorektaler Erkrankungen mit negativem rektalen Kontrastmittel

Publishing Information

Journal Title
RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der Neuen Bildgebenden Verfahren
Journal Volume
156
Journal Issue
3
Series
RoeFo - Fortschr. Geb. Roentgenstr. Neuen Bildgebenden Verfahr.
Journal Page Range
258-263
ISSN
0936-6652
CODEN
RFGVE

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
23086759
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CONTRAST MEDIA; DIAGNOSIS; DIGESTIVE SYSTEM DISEASES; DTPA; GADOLINIUM COMPLEXES; IMAGES; INFLAMMATION; INTESTINES; NEOPLASMS; NMR IMAGING; PATIENTS
Descriptors DEC
AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; COMPLEXES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DRUGS; GASTROINTESTINAL TRACT; MAMMALS; MAN; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH COMPLEXES; RESPONSE MODIFYING FACTORS; VERTEBRATES