Published October 1982
| Version v1
Journal article
Excision-repair patch size in DNA from human KB cells treated with UV-light, or methyl methanesulfonate
Creators
- 1. University of Western Ontario, London (Canada). Dept. of Biochemistry
Description
We have used the method of combined bromodeoxyuridine density label and radioactive label to measure the size of the repair patches appearing in the DNA of KB cells following treatment with UV-light or MMS. The repair patch size distribution was found to be the same for both agents, corresponding to the insertion of 34-40 nucleotides. These results, confirm recent results obtained by the bromodeoxyuridine-photolysis technique, that simple alkylating agents induce 'long patch' repair in human cells. (orig.)
Additional details
Publishing Information
- Journal Title
- Mutat. Res.
- Journal Volume
- 105
- Journal Issue
- 4
- Series
- CODEN: MUREA.;Mutat. Res.
- Journal Page Range
- 277-285
- ISSN
- 0027-5107
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 14778643
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL REPAIR; COMPARATIVE EVALUATIONS; DNA; MAN; MMS; MOLECULAR STRUCTURE; PHOTOLYSIS; ULTRAVIOLET RADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL RECOVERY; CHEMICAL REACTIONS; DECOMPOSITION; ELECTROMAGNETIC RADIATION; ESTERS; MAMMALS; MUTAGENS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; RADIATIONS; SULFONIC ACID ESTERS; VERTEBRATES