Published 2016 | Version v1
Journal article

Local defects of erythrocytes membranes nanostructure under the action of ultraviolet radiation on blood

  • 1. GBOU VPO Pervyj Moskovskij Gosudarstvennyj Meditsinskij Universitet im. I.M.Sechenova, Minzdrav Rossii, Moscow (Russian Federation)
  • 2. FGBNU 'Nauchno-Issledovatel'skij Institut Obshchej Reanimatologii im. V.A.Negovskogo, Moscow (Russian Federation)
  • 3. FGBNU 'Nauchno-Issledovatel'skij Institut Obshchej Reanimatologii im. V.A.Negovskogo', Moscow (Russian Federation)
  • 4. GBOU VPO Pervyj Moskovskij Gosudarstvennyj Meditsinskij Universitet im. I.M. Sechenova, Minzdrav Rossii, Moscow (Russian Federation)
  • 5. Ob''edinennyj Institut Yadernykh Issledovanij, Dubna (Russian Federation)

Description

The aim is to study the local topological defects of erythrocytes membranes resulting from the action of ultraviolet (UV) radiation on the blood, in vitro. Biological effects of the erythrocytes after exposure to UV radiation with a wavelength λ = 254 nm are much similar to the effects when exposed to γ radiation. It is shown that the oxidative processes that occur in the suspension under the action of UV radiation resulted in disruption of the membranes of erythrocytes nanostructure. In the experiments there were observed typical topological defects of membranes nanostructure. Parameters of defects differ from the characteristics of the control cell membrane nanostructure without irradiation. The characteristic dimensions of topological defects are commensurate with the size of spectrin matrix. As a result of exposure to UV radiation polymorphism of erythrocytes was observed

Availability note (English)

Available online: http://www1.jinr.ru/Pepan_letters/panl_2016_1/18_kozlov.pdf

Abstract (Russian)

Öåëüþ ðàáîòû ÿâëÿåòñÿ èçó÷åíèå ëîêàëüíûõ òîïîëîãè÷åñêèõ äåôåêòîâ ìåìáðàí ýðèòðîöèòîâ, âîçíèêàþùèõ â ðåçóëüòàòå äåéñòâèÿ óëüòðàôèîëåòîâîãî (ÓÔ) èçëó÷åíèÿ íà êðîâü, in vitro. Áèîëîãè÷åñêèå ïîñëåäñòâèÿ â ýðèòðîöèòàõ ïîñëå âîçäåéñòâèÿ ÓÔ-èçëó÷åíèÿ, ïðèâîäÿò ê íàðóøåíèþ íàíîñòðóêòóðû ìåìáðàí ýðèòðîöèòîâ.  îïûòàõ íàáëþäàëè òèïè÷íûå òîïîëîãè÷åñêèå äåôåêòû íàíîñòðóêòóðû ìåìáðàí. Ïàðàìåòðû äåôåêòîâ îòëè÷àëèñü îò õàðàêòåðèñòèê íàíîñòðóêòóðû ìåìáðàí êîíòðîëüíûõ êëåòîê áåç îáëó÷åíèÿ. Õàðàêòåðíûå ðàçìåðû òîïîëîãè÷åñêèõ äåôåêòîâ ñîèçìåðèìû ñ ðàçìåðàìè ñïåêòðèíîâîãî ìàòðèêñà.  ðåçóëüòàòå âîçäåéñòâèÿ ÓÔ-èçëó÷åíèÿ íàáëþäàëñÿ ïîëèìîðôèçì ýðèòðîöèòîâ

Additional details

Additional titles

Original title (Russian)
Локальные дефекты наноструктуры мембран эритроцитов при действии ультрафиолетового излучения на кровь

Publishing Information

Journal Title
Pis'ma v Zhurnal 'Fizika Ehlementarnykh Chastits i Atomnogo Yadra'
Journal Volume
13
Journal Issue
1/199
Journal Page Range
p. 220-232
ISSN
1814-5957

INIS

Country of Publication
Joint Institute for Nuclear Research (JINR)
Country of Input or Organization
Joint Institute for Nuclear Research (JINR)
INIS RN
47080063
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BIOLOGICAL EFFECTS; BLOOD; CELL MEMBRANES; DEFECTS; ERYTHROCYTES; IN VITRO; NANOSTRUCTURES; OXIDATION; TOPOLOGY; ULTRAVIOLET RADIATION
Descriptors DEC
BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL CONSTITUENTS; CHEMICAL REACTIONS; ELECTROMAGNETIC RADIATION; MATERIALS; MATHEMATICS; MEMBRANES; RADIATIONS

Optional Information

Notes
27 refs., 6 figs., 2 tabs.