High doses of chemotherapy and autologous transplant with stem cells hematopoietic

The demonstration of a dose effect relationship in the treatment of the different neoplasia s, both in solid tumors and in hematologic neoplasia s and, in particular, in the expire of the resistance to chemotherapy with myeloablative does shows increased interest in high doses of chemotherapy over the last few years.The advent of the stimulating factors of colonies of the granulocytic(G-CSF) and macrophage(GM-CSF) type, as well as the modern techniques for harvesting or peripheral hematopoietic progenitors whose re infusion in subsequent to myeloablative treatment enables fundamental acceleration of the hematopoietic recovery and consequent diminution of pos transplant complications.In the present report the authors carry out a revision of high dose indications of chemotherapy followed by hematopoietic autologous transplant in solid tumors, non Hodgkins lymphomas and multiple myeloma s