Published February 2019
| Version v1
Journal article
14β-(Isoxazol-3-yl)methylestrane Steroids: Chemoselective Synthesis and Transformations with Heterocyclic Ring Opening
- 1. National Academy of Sciences of Belarus, Institute of Bioorganic Chemistry (Belarus)
- 2. Blokhin National Medical Research Center of Oncology (Russian Federation)
Description
Steroids containing an isoxazole, isoxazoline, or enaminocarbonyl substituent at C-14 and a C-14-C-15-fused pyrrolidine ring were synthesized. The influence of solvents on the result of dipolar cycloaddition and solvolysis of bridged nitrosteroids was evaluated. Cytotoxicity testing of estrone analogs on cancer cells of various origins revealed activity against breast, colorectal, prostate, and lung cancer cells.
Additional details
Identifiers
Publishing Information
- Journal Title
- Russian Journal of Organic Chemistry
- Journal Volume
- 55
- Journal Issue
- 2
- Journal Page Range
- p. 202-214
- ISSN
- 1070-4280
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 51108812
- Subject category
- S60: APPLIED LIFE SCIENCES; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- CARBON 14; CARBON 15; CELL CULTURES; ESTRADIOL; ESTRONE; LACTAMS; LUNGS; MAMMARY GLANDS; NEOPLASMS; NITRILES; NUCLEAR MAGNETIC RESONANCE; OXIDES; PROSTATE; PYRROLIDINES; SOLVOLYSIS; TOXICITY; TUMOR CELLS
- Descriptors DEC
- AMIDES; AMINES; ANIMAL CELLS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CHALCOGENIDES; CHEMICAL REACTIONS; DECOMPOSITION; DISEASES; ESTRANES; ESTROGENS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; GLANDS; HETEROCYCLIC COMPOUNDS; HORMONES; HYDROXY COMPOUNDS; ISOTOPES; KETONES; LIGHT NUCLEI; MAGNETIC RESONANCE; MALE GENITALS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PYRROLES; RADIOISOTOPES; RESONANCE; RESPIRATORY SYSTEM; SECONDS LIVING RADIOISOTOPES; STEROID HORMONES; STEROIDS; YEARS LIVING RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2019 Pleiades Publishing, Ltd.