Research on time and dose effects of γ-induced programmed cell death
Creators
- 1. Academy of Military Medical Sciences, Beijing (China). Inst. of Radiation Medicine
Description
Time courses and dose responses of γ-induced programmed cell death (PCD) in murine thymocytes after in vivo irradiation were studied, two methods (analysis of DNA fragmentation and flow cytometry) to determine PCD were implemented. The radiation sensitivity of different tissues was compared. It could be observed that the peak incidence of PCD occurred in thymocytes 4∼6 h after irradiation. On the basis of this results, 6 h after irradiation was chosen for the determination of the dose response. The dose responses for thymocytes reached a plateau after dose of 20 Gy. Spleen and thymus, the radiosensitive organs, after 1 Gy γ-irradiation PCD could be detected, while the heart, brain and kidney, the non radiosensitive organs, PCD could only be detected after doses of 10 Gy and above
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 14
- Journal Issue
- 2
- Journal Page Range
- p. 111-115.
- ISSN
- 1000-3436
- CODEN
- FYYXEA
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 27067910
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BRAIN; CELL KILLING; DNA; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; HEART; KIDNEYS; MICE; RADIATION INJURIES; RADIOSENSITIVITY; SPLEEN; THYMOCYTES; THYMUS; TIME DEPENDENCE
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; LYMPHATIC SYSTEM; MAMMALS; NERVOUS SYSTEM; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES