Efficacy of 3,4,3-LIHOPO for reducing the retention of 238Pu in rat after inhalation of the tributyl phosphate complex
Creators
- 1. CEA, Bruyeres le Chatel (France). DSV/DPTE/LRT
- 2. Pierre et Marie Curie Univ., Paris (France). Lab. de Chimie des Organoelements
- 3. Paris Nord Univ. (France). Lab. de Chimie Structurale Biomoleculaire
- 4. Lawrence Berkeley Lab., CA (United States)
Description
The efficacy of 3,4,3-LIHOPO, a siderophore analogue, has been tested for removing 238Pu from rat after inhalation of plutonium as the tri-N-butylphosphate (TBP) complex. The amounts of Pu retained in the lung of untreated rat, 7 days after exposure ranged from 0.86 to 37 kBq. Results have been compared with DTPA, the current therapy of choice for man. The ligand 3,4,3-LIHOPO was more effective than DTPA for removing Pu from the body when repeated treatment began 1 h after inhalation. This observation was independent of the mass of Pu deposited in the lungs. The efficacy of 3,4,3-LIHOPO was mainly due to the decrease of Pu retention in lung, 1.5 times less than after DTPA administration; in liver and skeleton, retention was about four times less. (Author)
Additional details
Publishing Information
- Journal Title
- International Journal of Radiation Biology
- Journal Volume
- 64
- Journal Issue
- 4
- Journal Page Range
- p. 431-436.
- ISSN
- 0955-3002
- CODEN
- IJRBE7
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 25014520
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHELATING AGENTS; COMPARATIVE EVALUATIONS; DTPA; INHALATION; LUNGS; ORGANIC NITROGEN COMPOUNDS; PLUTONIUM 238; POST-IRRADIATION THERAPY; RATS; RETENTION
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; DRUGS; EVALUATION; EVEN-EVEN NUCLEI; HEAVY ION DECAY RADIOISOTOPES; HEAVY NUCLEI; INTAKE; ISOTOPES; MAMMALS; MEDICINE; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PLUTONIUM ISOTOPES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPIRATORY SYSTEM; RESPONSE MODIFYING FACTORS; RODENTS; SILICON 32 DECAY RADIOISOTOPES; SPONTANEOUS FISSION RADIOISOTOPES; THERAPY; VERTEBRATES; YEARS LIVING RADIOISOTOPES