Distribution and retention of Cd109 by the gastrointestinal tract and other organs following intraperitoneal cadmium exposure

Despite various information on the organ distribution of Cd, relatively little published data are available in the literature about the gastrointestinal absorption and retention of cadmium. Estimates show that absorption of cadmium by the gastrointestinal tract are between 5-10% of the ingested dose. Our recent studies indicated that some gastrointestinal hormones - cholecystokinin (CCK), pancreatic polypeptide (PP) and gastrin - were affected with cadmium was infused in combination with bombesin (BBS), a peptide known to stimulate the release of gastrointestinal hormones. whether Cd accumulates in parts of the digestive tract which synthesize these hormones is not known. This study was conducted to determine if Cd is accumulated and retained by organs of the gastrointestinal tract that synthesize these gastrointestinal hormones