Modulation of radiation-induced chromosome aberrations by DMSO-preliminary comparisons in three mammalian species
- 1. Oak Ridge Associated Universities, TN (USA)
Description
Earlier, the authors exposed human lymphocytes to X-radiation in medium containing DMSO. Objectives were to estimate the contribution of reactive radical species in inducing DNA lesions involved in the formation of chromosome aberrations. To determine whether DMSO was equally effective in protecting against exchange induction in lymphocytes of other mammalian species, they exposed human, pig, and rabbit lymphocytes to 99, 191, or 383 rad X-rays in medium with or without 1 M DMSO. Evaluations of induced dicentrics in M(I) metaphases from cultures without DMSO demonstrated differences in relative radiation sensitivity between the three species as expected. Pronounced, species-dependent reductions in X-ray induced dicentrics were observed in lymphocytes irradiated in the presence of DMSO
Additional details
Publishing Information
- Imprint Title
- DOE contractors' workshop: Cellular and molecular aspects of radiation induced DNA damage and repair
- Journal Page Range
- p. 100.
- Report number
- CONF-8703182--Summs
Conference
- Title
- Conference on cellular molecular aspects, radiation induced DNA damage and repair.
- Dates
- 10-11 Mar 1987.
- Place
- Albuquerque, NM (USA).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19099419
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Quality check status
- Yes
- Descriptors DEI
- CHROMOSOMAL ABERRATIONS; COMPARATIVE EVALUATIONS; DMSO; GENETIC VARIABILITY; LYMPHOCYTES; MAN; RABBITS; RADIATION EFFECTS; RADIOSENSITIVITY; SWINE; X RADIATION;
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL VARIABILITY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DOMESTIC ANIMALS; ELECTROMAGNETIC RADIATION; EVALUATION; IONIZING RADIATIONS; LEUKOCYTES; MAMMALS; MATERIALS; MUTATIONS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; RADIATIONS; SOMATIC CELLS; SULFOXIDES; VERTEBRATES;