Left ventricular diastolic function in patients with coronary heart disease (radionuclide ventriculography finding)

The study involved 129 patients suffering from coronary heart disease (CHD). Equillibrium radionuclide ventriculography was carried out. A complex of qualitative indices of the left ventricular (LV) diastolic function included peak filling rate (PFR), time to PFR (T-PFR), filling fraction (FF1) and volume (V1) in fast filling phase, filling fraction (FF2) and volume (V2) in slow filling phase, fraction (F3) and volume (V3) in left ventricular auricle systole period. PFR decrease and hemodynamics patten changes were revealed in patients with CHD and normal systolic (EF > 50.0%) and pumping (SV > 6.0%) functions of the LV (Group 1). Diastolic indices changes in patients with CHD and myocardial infarction and normal systolic and pumping functions were more pronounced. In patients with CHD and signs of II-A stage heart failure (EF < 45.0%), diastolic indices changes were expressed to an even greater degree along with impaired hemodynamic filling structure: V1 decrease, V2 increase and V3 moderate decrease. The data provided are indicative of disturbance of active and passive regulatory mechanisms of the LV diastolic function in patientss with CHD.