Analysis of radiation induced carcinogenesis using a two-stage carcinogenesis model: implications for dose-effect relationships

A recently developed two-stage model of carcinogenesis has been combined with the molecular model of radiation biology to describe radiation induced carcinogenesis. The model provides simultaneously the age-dependent incidence of spontaneous and radiation induced tumours and dose-effect relationships at any age after exposure. The model has been used to describe data on the incidence of lung tumours in mice and skin tumours in rats after acute exposure to different radiation types and also to the induction of bone sarcomas in female dial painters after prolonged exposure to 226Ra alpha particles. The model has characteristics of both relative and absolute risk projections depending on the age of exposure. (author)