Published September 1995
| Version v1
Journal article
Radiosensitization of thymine by Fe(III)-1,2 dihydroxyanthraquinone complex in dilute aqueous solution
Creators
- 1. Saha Inst. of Nuclear Physics, Calcutta (India). Nuclear Chemistry Div.
Description
A complex of Fe(III) with 1,2 dihydroxy 9, 10, anthraquinone (DHA) has been prepared. The metal ion forms a 1:3 complex with DHA. The complex is formed due to the dissociation of one proton per ligand bound to the metal ion. The stability constant of the Fe(III) complex is 1.61 x 1032. The complex reduces the catalytic flow of electrons from NADH to molecular O2 through NADH dehydrogenease over DHA. The Fe(III) complex is seen to be an efficient radiosensitizer towards γ-radiation induced degradation of thymine in a nitrous oxide saturated medium. (author). 31 refs., 2 figs., 1 tab
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 196
- Journal Issue
- 1
- Journal Page Range
- p. 57-63.
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 27013071
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AQUEOUS SOLUTIONS; CHEMICAL PREPARATION; GAMMA RADIATION; IRON COMPLEXES; QUINIZARIN; RADIOPHARMACEUTICALS; RADIOSTERILIZATION; STABILITY; THYMINE
- Descriptors DEC
- ANTHRAQUINONES; AROMATICS; AZINES; COMPLEXES; DISPERSIONS; DRUGS; DYES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; HOMOGENEOUS MIXTURES; HYDROXY COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; LABELLED COMPOUNDS; MATERIALS; MIXTURES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PYRIMIDINES; QUINONES; RADIATIONS; RADIOACTIVE MATERIALS; SOLUTIONS; STERILIZATION; SYNTHESIS; TRANSITION ELEMENT COMPLEXES; URACILS