Published July 1985
| Version v1
Journal article
Synthesis of (2R)- and (2S)-[3-2H]-valine
Creators
- 1. Canterbury Univ., Christchurch (New Zealand). Dept. of Chemistry
Description
(2R)-Valine and the (2S)-isomer were esterified and benzoylated. The derivatives were chlorinated at C-3 by treatment with sulphuryl chloride, reduced to the 3-2H derivatives by reaction with triphenyltin deuteride, then hydrolysed to give (2R)- and (2S)-[3-2H]-valine. The labelling is achieved with complete retention of optical purity. (author)
Additional details
Publishing Information
- Journal Title
- J. Labelled Compd. Radiopharm.
- Journal Volume
- 22
- Journal Issue
- 7
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 667-672
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 17012006
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; DEUTERIUM COMPOUNDS; ISOMERS; LABELLING; VALINE
- Descriptors DEC
- AMINO ACIDS; CARBOXYLIC ACIDS; HYDROGEN COMPOUNDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS