Published April 1987
| Version v1
Journal article
Fate of 7,12-dimethylbenz(a)anthracene absorbed from the rat intestine and transported in chylomicrons
Description
Chylomicrons obtained from the thoracic duct of rats fed [3H]7,12-dimethylbenz(a)anthracene (DMBA), a polycyclic aromatic hydrocarbon, were infused intravenously into rats with bile fistulas. Over 17 hr, 55.9 +/- 3.2% (mean +/- SEM) of the radioactivity was recovered in bile and 6.7 +/- 0.5% in urine. Minor amounts were deposited in liver, kidneys and epididymal fat pads. Injection of DMBA in ethanolic solution gave a similar pattern, while biliary DMBA metabolites resulted in higher recovery in urine and lower recovery in fat. In conclusion, the major part of chylomicron DMBA is rapidly excreted via the biliary route, while a fraction is probably retained in adipose tissue
Additional details
Publishing Information
- Journal Title
- Lipids
- Journal Volume
- 22
- Journal Issue
- 4
- Series
- Lipids.
- Journal Page Range
- 278-281
- ISSN
- 0024-4201
- CODEN
- LPDSA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19008480
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ADIPOSE TISSUE; BENZANTHRACENE; BILE; CHYLOMICRONS; INTESTINAL ABSORPTION; METABOLISM; METABOLITES; RATS; TISSUE DISTRIBUTION; TRACER TECHNIQUES; TRITIUM COMPOUNDS
- Descriptors DEC
- ANIMALS; AROMATICS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CONDENSED AROMATICS; CONNECTIVE TISSUE; DISTRIBUTION; HYDROCARBONS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; RODENTS; TISSUES; UPTAKE; VERTEBRATES