Published September 1984
| Version v1
Journal article
Treatment of locally advanced head and neck cancer with misonidazole, hyperbaric oxygen and irradiation: an interim report
Description
Thirty-one patients with advanced inoperable squamous carcinoma of the mouth were treated in a pilot study with misonidazole with each of six fractions of 6.0 Gy in hyperbaric oxygen at 3 ATA. The one and two year disease free survival was 48 and 26%, respectively. A prospective randomized trial is now being conducted comparing this regimen with 63.0 Gy in 30 fractions in 38 days in air. One hundred-fourteen patients have been entered; 91 are available for analysis at six months or more. The preliminary results at 6 and 12 months favor the combination of sensitizers. There is no added toxicity
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Volume
- 10
- Journal Issue
- 9
- Series
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Page Range
- 1721-1723
- ISSN
- 0360-3016
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16060524
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARCINOMAS; ERYTHEMA; FRACTIONATED IRRADIATION; MISONIDAZOLE; NAUSEA; ORAL CAVITY; OXYGEN; PATIENTS; RADIATION EFFECTS; RADIOSENSITIVITY; RADIOTHERAPY; SIDE EFFECTS
- Descriptors DEC
- ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELEMENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; IRRADIATION; MEDICINE; NEOPLASMS; NITRO COMPOUNDS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; SYMPTOMS; THERAPY