Synthesis and pharmacokinetics of two new derivatives of the iminodiacetic acid

Two new derivatives were synthesized on which changes were made at level of the chain that joins the lipophilic group with the hydrophilic one: N-(2,6 diisopropylphenylcarbamoylethyl 1-) iminodiacetic acid (HIDA 5) and N-(4 butylphenylcarbamoylethyl 1-) iminodiacetic acid (HIDA 6). The synthesis was done following the same method used to obtain the other known derivatives: reaction of the aniline with chloropropionyl chloride giving the α-chloride, and subsequent nucleophilic substitution of the w-chloride with iminodiacetic acid to yield the desired IDA congener. The structure of these new derivatives was confirmed by analysis of the centesimal composition, mass spectrometry an MNR. In order to determine the cinetic of these two new derivatives groups of mice were used as models