Published April 2012
| Version v1
Journal article
Synthesis and conformation of novel 3'-branched threo syl-5'-deoxy phosphonic acid nucleoside analogues
- 1. Chosun Univ., Kwangju (Korea, Republic of)
Description
The discovery that threo syl phosphonate nucleoside (PMDTA, EC50 = 2.53 μM) is a potent anti-HIV agent has led to the synthesis and biological evaluation of 5'-deoxy versions of threo syl phosphonate nucleosides. In the present study, (E)-3'-phosphono alkenyl and 3'-phosphono alkyl nucleoside analogues 13, 16, 20 and 23 were synthesized from acetol and tested for anti-HIV activity and cytotoxicity. The adenine analogue 16 was found to exhibit moderate in vitro anti-HIV-1 activity (EC50 = 22.2 μM)
Additional details
Publishing Information
- Journal Title
- Bulletin of the Korean Chemical Society
- Journal Volume
- 33
- Journal Issue
- 8
- Series
- 22 refs, 5 figs, 1 tab
- Journal Page Range
- p. 2574-2580
- ISSN
- 0253-2964
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 45088458
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ADENINES; IN VITRO; NUCLEOSIDES; PHOSPHONIC ACIDS; SYNTHESIS
- Descriptors DEC
- AMINES; ANTIMETABOLITES; AROMATICS; AZAARENES; DRUGS; HETEROCYCLIC COMPOUNDS; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PURINES; RIBOSIDES