Published April 2006
| Version v1
Journal article
Orientations of water molecules surrounding B-DNA observed by neutron crystallographic analysis
- 1. Japan Atomic Energy Agency, Quantum Beam Science Directorate, Tokai, Ibaraki (Japan)
- 2. Chiba Inst. of Science, Faculty of Pharmaceutical Science, Choshi, Chiba (JP)
- 3. Ibaraki Univ., Graduate School of Science and Engineering, Inst. of Applied Beam Science, Hitachi, Ibaraki (JP)
Description
By neutron diffraction measurements of B-DNA duplex, we have succeeded in determining the D positions in 27 D2O molecules. Moreover, the complex water network in the minor groove has been observed in detail. By a combined structural analysis using X-ray and neutron data, it is clear that the spine of hydration is built up, not only by a simple hexagonal hydration pattern, but also by many other water bridges hydrogen-bonded to the DNA strands. The complexity of the hydration pattern in the minor groove is derived from an extraordinary variety of orientations displayed by the water molecules. (author)
Additional details
Publishing Information
- Journal Title
- Nippon Kessho Gakkai-Shi
- Journal Volume
- 48
- Journal Issue
- 2
- Journal Page Range
- p. 133-139
- ISSN
- 0369-4585
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 37082423
- Subject category
- S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
- Descriptors DEI
- DEUTERIUM; DEUTERONS; DNA; GENOME MUTATIONS; HYDRATION; HYDROGEN; NEUTRON DIFFRACTION; OXYGEN; PROTEIN STRUCTURE; PROTEINS; RNA; SPRING-8 STORAGE RING; WATER; X-RAY DIFFRACTION
- Descriptors DEC
- CHARGED PARTICLES; COHERENT SCATTERING; DIFFRACTION; ELEMENTS; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MUTATIONS; NONMETALS; NUCLEI; NUCLEIC ACIDS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RADIATION SOURCES; SCATTERING; SOLVATION; STABLE ISOTOPES; STORAGE RINGS; SYNCHROTRON RADIATION SOURCES
Optional Information
- Notes
- 35 refs., 6 figs., 1 tab.