Published December 2019
| Version v1
Book
Mechanistic aspects of fungicide induced DNA damage: spectroscopic and molecular dynamics simulation studies
Creators
- 1. School of Chemical Sciences, Indian Association for the Cultivation of Science, Kolkata (India)
Description
The DNA damage mechanism induced by fungicide 'Dodine' has been investigated using several spectroscopic, thermal and molecular dynamics simulation techniques. Dodine interacts specifically with adenine (A)-thymine (T) bases of the minor groove of DNA mainly by its long hydrophobic chain. The interaction of do dine perturbs the stacking of nucleobases in the minor groove as well as elongates the first strand of DNA which leads to damage of its canonical structure. (author)
Additional details
Publishing Information
- Publisher
- Bhabha Atomic Research Centre
- Imprint Place
- Mumbai (India)
- ISBN
- 978-81-940321-5-1
- Imprint Title
- Proceedings of the fifteenth DAE-BRNS biennial Trombay symposium on radiation and photochemistry: book of abstract
- Imprint Pagination
- 184 p.
- Journal Page Range
- p. 59
Conference
- Title
- 15. DAE-BRNS biennial Trombay symposium on radiation and photochemistry
- Acronym
- TSRP-2020
- Dates
- 5-9 Jan 2020
- Place
- Mumbai (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 54095205
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ADENINES; CANONICAL DIMENSION; DNA DAMAGES; FUNGICIDES; SIMULATION; THYMINE
- Descriptors DEC
- AMINES; ANTIMETABOLITES; AROMATICS; AZAARENES; AZINES; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; HYDROXY COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PESTICIDES; PURINES; PYRIMIDINES; SCALE DIMENSION; URACILS