Published 1982
| Version v1
Journal article
Quality control of krypton-81m generator
Creators
- 1. C.H.R.U., Grenoble (France)
- 2. Institut des Sciences Nucleaires, Grenoble (France)
Description
The control of quality of the short half life radiopharmaceutical krypton-81m in solution is detailed. Because it is not possible to test sterility, to measure the pH and the activity of the contaminants and to search pyrogen in the solution which will be injected, a compromise must be done. If the characteristics of the eluat of the generator (pH, activity of the contaminants) are stable and in acceptable limits during 3 hours, the perfusion must be done with an acceptable risk. The apyrogenicity of the eluat must be tested with the rabbit pyrogen test and with the L.A.L. before injection. The control of sterility must be done though the results are obtained long after the perfusion
Abstract (French)
Le controle de qualite des solutions injectables contenant un radioelement a vie courte pose un certain nombre de problemes que la legislation actuelle ne permet pas de resoudre. Lors de l'emploi d'un generateur de krypton-81m en solution un compromis est necessaire: il consiste a supposer que si pendant quelques heures le pH de l'eluat et l'activite des contaminants qu'il contient restent stables et dans les limites acceptables, et que si son caractere apyrogene a ete demontre, il est possible de l'injecter sans risques des sa sortie du generateur. Pour rechercher les substances pyrogenes il est recommande d'associer le test in vivo chez le lapin au test L.A.L. Les controles de sterilite sont indispensables bien que leurs resultats soient obtenus a posterioriAdditional details
Additional titles
- Original title (French)
- Controles de qualite d'un generateur de krypton-81m
Publishing Information
- Journal Title
- J. Biophys. Med. Nucl.
- Journal Volume
- 6
- Journal Issue
- 3
- Series
- J. Biophys. Med. Nucl.
- Journal Page Range
- 121-124
- ISSN
- 0399-0435
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 14741002
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- KRYPTON 81; QUALITY CONTROL; RADIOISOTOPE GENERATORS; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; CONTROL; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KRYPTON ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; YEARS LIVING RADIOISOTOPES