Sup(99m)Tc-Cu-citrate: a new complex for renal function studies

A method for preparing sup(99m)Tc-citrate complex using instantly formed cuprous ions for the reduction of pertechnetate is described. The labelling kinetics, formation rate and stability of sup(99m)Tc-Cu-citrate complex was studied. Gel filtration using column scanning technique was found to be a reliable und unique tool for determining the amount of sup(99m)Tc fractions as a function of time in the preparation. The kidney uptake and excretion characteristics suggest a potential usefulness of sup(99m)Tc-Cu-citrate complex for renal function studies. The safety measures for the amount of the complex to be injected in man were estimated. (author)