Alterations in certain Enzymatic Activities in Liver and Serum of Male Rats Treated with Endotoxin Or Exposed To Gamma Radiation
Creators
- 1. National Center for Radiation Research and Technology, AEA, Cairo (Egypt)
Description
This study was performed to determine the effects of endotoxins and gamma radiation on glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), acid phosphatase (ACP) and alkaline phosphatase (ALP). Endotoxin (isolated from Escherichia coli, Serotype 055) was supplemented to rats by gavage with a dose level of 20 mg/kg /day for a period of four weeks. Whole body gamma irradiation was carried out by exposure of rats to 4 Gy delivered as 0.5 Gy twice weekly. The results demonstrated that endotoxin administration as well as exposure to gamma radiation produced significant increases in the activities of liver transaminases and acid phosphatase enzymes 1,2 and 4 weeks post treatment. In the serum of endotoxin treated rats, the activities of transaminases showed non-significant changes while significant increases were observed in the serum of irradiated rats
Additional details
Publishing Information
- Journal Title
- Isotope and Radiation Research
- Journal Volume
- 36
- Journal Issue
- 1
- Journal Page Range
- p. 113-121
- ISSN
- 0021-1907
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Egypt
- INIS RN
- 36029136
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACID PHOSPHATASE; ALKALINE PHOSPHATASE; BIOCHEMISTRY; BLOOD SERUM; ENDOTOXINS; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; GAMMA RADIATION; LIVER; MALES; RATS; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; ANTIGENS; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CHEMISTRY; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ENZYMES; ESTERASES; EXTERNAL IRRADIATION; GLANDS; HAZARDOUS MATERIALS; HYDROLASES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PHOSPHATASES; PROTEINS; RADIATIONS; RODENTS; TOXIC MATERIALS; TOXINS; VERTEBRATES